Five carbapenems have been used to treat serious infections in clinical trials. 骨架和侧链的化学合成是碳青霉烯类药物研究和开发的重点和热点方向。
In the nineteen-eighties, a class of drugs called carbapenems was developed to combat gram-negative organisms like Klebsiella, Pseudomonas, and Acinetobacter. 在二十世纪八十年代，一种叫碳青霉烯的药物被开发出来，专门对付像克雷伯氏菌，革兰氏阴性细菌，假单胞菌和不动菌。
