She had a certain charge as to the school, and very well she did her work. I shall have a great loss in her if she leaves. 对学校来说她负有相当的职务，而且她工作做得挺好。她若走了，对我将是一个极大的损失。
Her departure is a great loss to the orchestra. 她离去是管弦乐队的一大损失。
It was a great loss to us all. 这对我们所有人来说都是一个巨大的损失。
I had the privilege of knowing your brother in years past, and I realize your great loss. 多年前我有幸结识您哥哥，因此我知道他的逝世是您的巨大损失。
