The proteasome is primarily responsible for intracellular protein degradation.The abnormality of its activity is sign of tumorigenesis. 蛋白酶体负责细胞内蛋白的降解，其活性的异常改变是肿瘤发生的标志。
In addition, following chemotherapy, there was a significant decrease in proteasome levels in patients who responded compared to those who did not. 此外，对化疗有反应的患者在治疗后蛋白酶体水平有显著的降低。
